Pharmaceutical Biocatalysis: Drugs, Genetic Diseases, and Epigenetics pdf

Peter Grünwald heads the machine learning group at CWI in Amsterdam, the Netherlands. He is also full professor of Statistical Learning at the mathematical institute of Leiden University. Currently the President of the Association for Computational Learning, the organization running COLT, the world’s prime annual conference on machine learning theory, he was co-program chair of COLT in 2015 and also chaired UAI – another top ML conference – in 2010/2011. Apart from publishing at ML venues like NIPS, COLT and UAI, he also regularly contributes to statistics journals such as the Annals of Statistics. He is the author of the book The Minimum Description Length Principle, (MIT Press, 2007; see here for an up-to-date (2020), much shorter introduction), which has become the standard reference for the MDL approach to learning. In 2010 he was co-awarded the Van Dantzig prize, the highest Dutch award in statistics and operations research. He received NWO VIDI (2005), VICI (2010) and TOP-1 (2016) grants.

Pharmaceutical Biocatalysis: Drugs, Genetic Diseases, and Epigenetics pdf by Peter Grünwald

Volume 7 of the Jenny Stanford Series on Biocatalysis deals with several different aspects of pharmaceuticals, which include not only various applications of drugs and their metabolism but also natural resources for active pharmaceutical ingredients as well as the removal of pharmaceutical pollution. In detail, novel approaches for developing microbial fermentation processes to produce vitamin B6 using microorganisms are described together with novel routes for vitamin B6 biosynthesis. The other topics discussed are new approaches for producing the successful anticancer drug Taxol from naturally occurring precursors, molecular farming through plant engineering as a cost-effective means to produce therapeutic and prophylactic proteins, and successful screening of potent microorganisms producing L-asparaginase for various chemotherapeutic applications. Furthermore, microbial biotransformations in the production and degradation of fluorinated pharmaceuticals are described. The other chapters inform the reader about the biotransformation of xenobiotics/drugs in living systems, the degradation of pharmaceuticals by white-rot fungi and their ligninolytic enzymes, and the removal of pharmaceutical pollution from municipal sewage using laccase.